Born in Rochester, New York, Marie Howe attended Sacred Heart Convent School and the University of Windsor. She received an MFA from Columbia University, where she studied with Stanley Kunitz, whom she refers to as “my true teacher.”

Howe has taught at Sarah Lawrence College, Columbia, and NYU. She co-edited (with Michael Klein) the essay anthology In the Company of My Solitude: American Writing from the AIDS Pandemic (1994). She has received fellowships from the Bunting Institute at Radcliffe College, the National Endowment for the Arts, the Guggenheim Foundation, and the Fine Arts Work Center in Provincetown.